“Measuring Health:
How to apply nutrigenomics for measuring metabolic health”

Tuesday 6th September 2011

16.00-18.30   Registration and mounting posters

18:30-20.00   Welcome and Session 1: Novel topics / Hot of the press
Chair: Michael Müller
18.30-18.45   Michael Müller (Wageningen University, NL) Download Presentation in pdf
18.45-19.20   Daniel G. MacArthur (Welcome Trust Sanger Institute, UK) Download Presentation in pdf
Personal Genomics: From personal genomes to personal health
19.20-20.00   Machteld Huber  (Louis Bolk Institute, NL) Download Presentation in pdf
                         Is health a state or an ability? Towards a dynamic concept of health
20.00-21:30   Poster Session 1 and Welcome reception

Wednesday 7th September 2011
08:30-10:30    Session 2: Brain & nutrient sensing
                          Chair: Sander Kersten
08.30-09.00    Christoph Buettner (the Mount Sinai Medical Center, USA)
Brain insulin controls adipose tissue lipolysis and lipogenesis
09.00-09.30    Rajat Singh (Albert Einstein College of Medicine, USA) Download Presentation in pdf
Hypothalamic autophagy and regulation of energy balance
09.30-09.45    Oral 1: Mona Mischke (Charité Berlin, DE)
The DNA methylation pattern of proopiomelanocortin (POMC) is stably established in early ontogenesis and influences gene expression
09.45-10.00    Oral 2: X. Zhang (University of Aberdeen, Rowett Research Institute)
Amounts and activation status of plasma cell-derived microparticles differ between subjects who are healthy, obese or have Type 2 diabetes
10.00-10.15    Oral 3: Doris Jacobs (Unilever R & D, NL)
Green tea extract induces different metabolic responses during rest and moderate intensity exercise
10.15-10.30    Discussion time

10:30-11:00    Coffee/tea break

11:00-12:45    Session 3: The healthy gut
                          Chair: Dirk Haller
11.00-11.30    Willem de Vos (Wageningen University, NL/University of Helsinki, FI)
Modulation of gut microbiota to improve human health
11.30-12.00    Ciska Wijmenga (University of Groningen, NL) Download Presentation in pdf
Role of environment and genetics for gut inflammation
12.00-12.15    Oral 4: Eva Rath (Technical University Munich, DE)
dsRNA-activated protein kinase links mitochondrial unfolded protein response to intestinal inflammation in humans and mice
12.15-12.30    Oral 5: Noortje IJssennagger (Wageningen University, NL) Download Presentation in pdf
Dietary heme stimulates epithelial cell turnover by downregulating feedback inhibitors of proliferation
12.30-12.45    Oral 6: Lieselotte Cloetens (Lund University, SE) Download Presentation in pdf
Methods to assess the effects of prebiotics
12.45-13.00    Discussion time

13:00–14:45   Lunch and poster session 2

14:45–16:30   Session 4: Challenging the liver
Chair: Helen Roche
14.45-15.15    Norbert Stefan (University of Tübingen, DE)
NASH: When fat becomes a problem
15.15-15.45    Carolyn Cummins (University of Toronto, CA) @Download Presentation in pdf
Use of animal models in nutritional physiology and pathology: studies using liver X receptor knockouts
15.45-16.00    Oral 7: Peter Wielinga (TNO, NL) Download Presentation in pdf
Beneficial effects of alternate dietary regimen on liver inflammation, atherosclerosis and renal activation
16.00-16.15    Oral 8: Ludger Scheja (University Medical Center Hamburg-Eppendorf (DE) Download Presentation in pdf
Regulation of Liver and Adipose Tissue Lipogenesis in Human Obesity
16.15-16.30    Discussion time

16.30-17.00    Coffee/tea break

17.00-18.30    Session 5: Metabolic health
Chair: Marjukka Kolehmainen
17.00-17.30    Patrick Schrauwen (University Maastricht, NL
skeletal muscle metabolic health: role of muscle fat, mitochondrial function and lipoxicity
17.30-17.45    Oral 9: Frode Norheim (University of Oslo, NO) Download Presentation in pdf
                          Proteomic identification of secreted proteins from human skeletal muscle cells and expression in response to strength training
17.45-18.15    Hubert Vidal (INSERM-Lyon, FR) Download Presentation in pdf
Early molecular events of adipose tissue development during overfeeding in humans
18.15-18.30    Discussion time

18.30 Free time

Thursday 8th September 2011
8:30 – 10:30   Session 6: Adipose tissue
Chair: Christian Drevon
08.30-09.00   Mikael Ryden (Karolinska Institute, SE) Download Presentation in pdf
The role of adipose tissue in conditions of weight gain and loss
09.00-09.30   Ling Qi (Cornell University, USA)
Adipose Tissue, Inflammation and Obesity
09.30-09.50   Oral 10: Rinke Stienstra (Radboud University Nijmegen, NL) Download Presentation in pdf
Absence of Caspase-1 Protects Against Diet-Induced Obesity and Insulin Resistance: Identification of Underlying Mechanisms
09.50-10.10   Oral 11: Helen Roche (University College Dublin, IE) Download Presentation in pdf
Exploratory analysis of the inflammed adipocyte secretome to elucidate proteomic signatures of the effect of chronic low grade inflammation on the
metabolic environment

10.10-10.25   Discussion time

10:25-11:00   Coffee/tea break

11:00-12:15   Session 7: Metabolomics
Chair: Thomas Hankemeier
11.00-11.30   Elaine Holmes (Imperial College London, UK) Download Presentation in pdf
Using metabolomics to quantify health
11.30-12.00   Robert E Gerszten (Havard University, USA)
Metabolite profiles and the risk of developing diabetes
12.00-12.15   Oral 12: Ciara Morris (University College Dublin, IE) Download Presentation in pdf
The relationship between fitness levels and metabolomic profiles in healthy adults
12.15-12.30   Oral 13: Lars Dragsted (University of Copenhagen, DK)
Metabolomics in epidemiology – a strategy for analysis of complex human data sets
12.30-12.45   Discussion time

13.00-17.00   Lunch Packages and Visit to Kröller Muller Museum Otterloo (13.00-13.45 16.30-17.15)
17.30-18.00   Drinks and snacks

18.00-20.00   Session 8: Genome health
Chair: Sander Kersten
18.00-18.30  Jan Hoeijmakers (Erasmus Medical Center, NL)
The impact of genome maintenance on health and disease
18.30-19.00   Christine Könner(University Cologne, DE)
Regulation of energy homeostasis and Inflammation
19.00-19.15   Oral 14: Jill McKay (Newcastle University, UK) Download Presentation in pdf
Consequences of folate depletion during development for DNA methylation and gene expression in the fetal mouse.
19.15-19.30   Oral 15: Nathan O’Callaghan (CSIRO, AUS) Download Presentation in pdf
Colonocyte telomere shortening is greater with dietary red meat than white meat and is attenuated by resistant starch
19.30-20.00   Discussion time

20.30-00:00   Dinner at HvW and Poster prize and “Disco”

Friday 9th September 2011
09.00-10.30   Session 9: Integration of genomics data
Chair: Chris Evelo
09.00-09.30   Peter van der Spek (Erasmus Medical Center, NL)
Next Generation Sequencing of Diploid Human Genomes
09.30-09.50   Oral 16: Carsten Carlberg (University of Luxembourg, LU)
Genome-wide view on nuclear sensors for vitamin D and oxysterols
09.50-10.10   Oral 17: Keith Grimaldi (National Technical University of Athens, GR) Download Presentation in pdf
EUROGENE – Personal genetics in practice
10.15-10.30   Discussion time

10.30-11.00   Coffee/tea break

11.00-12.00   Session 10: Defining health
Chair: Michael Müller
11.00-11.45    Invited 18: Luigi Fontana (Washington University, USA / Italian National Institute of Health, IT) Download Presentation in pdf
How to stay healthy? Eat less?
11.45–12.15  Conclusions: Michael Müller (Wageningen University, NL) Download Presentation in pdf
What is healthy?
12.15-12.30    Closure: Ben van Ommen (TNO, NL: CEO NuGO Association)
12:30-13:30   Take-away lunch

Friday 9th September 2011
13.00-15.30   NuGO Participants Assembly Meeting