Wednesday 16 May (14.00 - 19.00)

14.00 Introduction to the scope and outcome of the symposium, Ben van Ommen (Presentation)
 
Session 1: Homeostasis and defining health - challenge tests in a nutritional context
 
14.15-14.45 The challenge of challenge test in nutrition research. Bruce German

14.45-15.15 Application of the intravenous lipid tolerance test in nutrigenetics research. Martin Weickert

15.15-15.45 Nutritional challenge tests in phenotypic quantification of an obesity cohort. Iwona Wybranska

15.45-16.15 Multi-omics layer quantification of the oral glucose tolerance test in mildly obese subjests. Suzan Wopereis
 
Session 2: Lessons from other scientific areas
 
16.45-17.15 In vivo imaging in obesity research. Jimmy Bell

17.15-17.45 Challenge tests in phenotypic quantification of transgenic mice. Helmut Fuchs
 
Session 3: Particpant input
 
17.45-19.00 Five-minute presentations by participants of challenge test ideas. Participants are invited to bring their ideas on nutritional challenges "to the table". These will be discussed during dinner...

• Challenge tests – some concepts John Mathers
• Modulation of robustness of homeostasis as a mechanism behind hormesis Kirsten Brandt
• PBMC transcriptomics - the challenge to find the right signatures Lydia Afman
• Stress Métabolique et Micronutriments and Micronutriments, Métabolisme et Signatures Biologiques Andre Mazur

Thursday 17 May (9.00  - 17.00 hour)
 
Session 4: Homeostatic strenght and nutritional modulation - interplay of metabolic, inflammatory and oxidative stress
 
09.00-09.30 Molecular mechanisms of nutritional perturbation related to metabolic and inflammatory stress. Michael Müller

09.30-10.00 Molecular mechanisms in metabolic and oxidative stress - role of mitochondria. Richard Porter

10.00-10.30 Metabolomic assessment of biomarkers related to dietary restriction - health lessons learned from ageing. Bruce Kristal
 
Session 5: 1st Parallel group discussion sessions
 
10.45-12.30 The scientific basis for challenging homeostasis

• Mike Gibney - Is plasma metabolomics revealing our health status?
• Michael Muller - Animal models in the quantification of human health
• Boukje de Roos - From molecule to organism (the systems biology dimension)
• Ben van Ommen - Metabolic imbalance: the interplay between metabolism, oxidation and inflammation

Session 6: Challenge test in a brader nutritional perspective
 
13.30-14.00 Endocrinal aspects of homeostatic strenght and nutritional modulation. Andrzej Bartke

14.00-14.30 Challenges in assessment of health strengthening by food bioactives. Jaap Keijer

14.30-15.00 A broader view on biomarkers of health. Michael Catt
 
Session 7: 2nd Parallel group discussion sessions

15.15-17.00 Getting quantification of health into practice

• Jaap Keijer Acute and chronic effects of balancing micronutrients 
• Jim Kaput - Hormonal and central control of homeostasis (the whole body physiology dimension) 
• John Mathers - Is it possible to standardise challenge tests in nutrition studies?

Friday 18 May (9.00 - 13.00)
 
Session 8: Reporting of working group discussions
 
9.00-10.30 Chairs of working groups report on outcomes of discussion (see above)
 
Session 9: Conclusions and the way forward
 
11.00-11.30 Towards a nutritional phenotype database. Ben van Ommen

11.30-12.00 A disease and health knowledge system. Michael Liebman

12.00-12.30 The (future) practice of nutritional efficacy assessment. Albert Flynn

12.30-13.00 Conclusions and recommendations of the symposium. Ben van Ommen