Contact UsCaloric restriction is a topic that links nutrition to ageing. Over the years, numerous hypotheses regarding the mechanism have been raised and partly abandoned . The latest "hormonesis" hypothesis, linked to the SIR pathways, may survive or not, but at least this story tells us that caloric restriction results in a set of complex processes with chronic implications.
Caloric restriction has been studied in numerous organisms, and in several of these, detailed mechanisms have been described. Logically, the complexity increases with climbing the evolutionary ladder. What can we learn form the mechanisms elucidated in yeats and C. elegans? How can we translate this into human nutrition?
Many nutritional scientists question the use of lower organisms in nutrition research. The caloric restriction story tells us that the question is not whether nutritionists like this or not, but that the fundamental biology arena reaches out to nutriton, and may readily absorb or claim part of the area. So, as we claim to shape nutritional systems biology, it`s time to condider how to climb down this ladder...
In the linked page, you can give your input and opinion.
Some recent papers describing the hypothesis and the work done in these organisms are attached.
