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Session 6 - Nutritional modulation of the ageing trajectory
Chair: John Mathers (UNew, UK)
Wednesday, 2nd September 17.30-19.30
| 17.30 | Bruce Ames (Un California, Berkeley) Delaying age-related disease with micronutrients: triage theory | |
| 18.00 | Colin Selman (Un Aberdeen, UK) Nutritional modulation of insulin signalling and its impact on lifespan and glucose homeostasis in mice | |
| 18.30 | Bas Heijmans (Leiden Un MC, NL) Persistent epigenetic differences associated with prenatal exposure to famine in humans | |
| 19.00 | Sue Ozanne (Cambridge, UK) Mechanisms responsible for effects of early life nutrition on ageing trajectory | |
Increased longevity and the associated burden of age-related morbidity pose major challenges for most societies. There is growing consensus that ageing results from the accumulation of unrepaired cellular damage and there is strong evidence that the ageing process is highly plastic being modulated by lifestyle factors (diet and physical activity) together with social circumstances. However, there is limited evidence about which dietary factors applied at what stages of the life-course can prevent or remove cellular damage and improve wellbeing in later life. This session will focus on molecular mechanisms responsible for the ageing phenotype and potential for nutritional modulation.